Center for Vaccine Research

Bruce McClane, PhD

  • Professor

Dr. McClane is a Professor in the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine. He is also a member of the Molecular Virology and Microbiology Graduate Program and Co-Course Director of the Medical Microbiology course for first year medical students. He received his Ph.D. in Microbiology and Cell Biology in 1980 from Penn State University and then performed postdoctoral research at the New York University School of Medicine. His research interests focus on toxin-mediated enteric diseases caused by Clostridium perfringens. Dr. McClane has served on the Editorial Board of Infection and Immunity for the past 13 years, won the Sydney Finegold award for Anaerobic Microbiology research in 1996, and has been elected as a Fellow of the American Academy of Microbiology.

Representative Publications

  • Robertson SL, McClane BA. Interactions between Clostridium perfringens enterotoxin and claudins. Methods Mol Biol. 2011;762:63-75. PMID:21717349
  • Li J, Chen J, Vidal JE, McClane BA. The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603. Infect Immun. 2011 Jun;79(6):2451-9. Epub 2011 Apr 4. PMID:21464088
  • Miyamoto K, Yumine N, Mimura K, Nagahama M, Li J, McClane BA, Akimoto S. Identification of novel Clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene. PLoS One. 2011;6(5):e20376. Epub 2011 May 31. PMID:21655254
  • Caserta JA, Robertson SL, Saputo J, Shrestha A, McClane BA, Uzal FA. Development and application of a mouse intestinal loop model to study the in vivo action of Clostridium perfringens enterotoxin. Infect Immun. 2011 May 31. [Epub ahead of print]PMID:21628512
  • Uzal FA, McClane BA. Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections. Vet Microbiol. 2011 Feb 26. [Epub ahead of print] PMID:21420802
  • Ma M, Vidal J, Saputo J, McClane BA, Uzal F. The VirS/VirR two-component system regulates the anaerobic cytotoxicity, intestinal pathogenicity, and enterotoxemic lethality of Clostridium perfringens type C isolate CN3685. MBio. 2011 Jan 25;2(1):e00338-10. PMID:21264065
  • Gurjar A, Li J, McClane BA. Characterization of toxin plasmids in Clostridium perfringens type C isolates. Infect Immun. 2010 Nov;78(11):4860-9. Epub 2010 Sep 7. PMID:20823204
  • Park M, Rooney AP, Hecht DW, Li J, McClane BA, Nayak R, Paine DD, Rafii F. Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens. Arch Microbiol. 2010 Oct;192(10):803-10. Epub 2010 Jul 27. PMID:20661548
  • Li J, McClane BA. Evaluating the involvement of alternative sigma factors SigF and SigG in Clostridium perfringens sporulation and enterotoxin synthesis. Infect Immun. 2010 Oct;78(10):4286-93. Epub 2010 Jul 19. PMID:20643850
  • Briggs DC, Smedley JG 3rd, McClane BA, Basak AK. Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):794-7. Epub 2010 Jun 24. PMID:20606275